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Post Info TOPIC: How does NBE work?


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Fecha: Jun 16, 2007
How does NBE work?


Here is my understanding of BE and how we are approaching it.

The endocrine system has several components to it. The following is
in relation to BE and steroid hormones. There are some things
intentionally overlooked due to time constraints and immediate
relevance.

The Endocrine System is driven by positive and negative feedback.
Blood hormone levels are monitored. The intricate details are not
necessary in order to understand or use this theory.

1. Steroid Hormone Pathways:
(see
http://www.yourmenopausetype.com/steroidpathway/steroidpathway.htm)

The following diagram shows a very condensed rendition of the
pathways BE'ers are interested in. To simplify, it seems to be
thought of in this way:

https://img14.photobucket.com/albums/v43/Wahaika/BasicSteroidPathway2.
gif

It appears that hormone levels behave the way they do because of
positive and negative feedback in the endocrine system. The system
obviously needs to maintain what estrogen dependent tissue is
already there. The system has the ability to regulate estrogen and
other hormones. How does the system determine if there is a need for
more estrogen?

The assumption is that there is some sort of mechanism where the
system detects that there is a need for estrogen to be produced.
This could be measured by producing some amount of estrogen, waiting
a certain amount of time and then measuring what the levels are. The
degree to which serum levels have fallen dictate how much estrogen
should be produced, if any. The idea being that if there is less
estrogen than expected, then it must have been consumed by
additional estrogen receptors, therefore more estrogen must be
needed.

By using herbs to fill receptors, BE'ers are bypassing this system
to create more cells and therefore more receptors. This creates a
need for more real estrogen to maintain the additional tissue. When
the hypothalamus/pituitary axis polls the estrogen levels, they
should appear lower because more real estrogen has been consumed by
the new tissue. More real estrogen is produced to keep up with the
demand, the goal being to keep estrogen levels stable, or at some
constant.

This is dependent on the system to work as expected. For those with
endometriosis, hysterectomy, or on BCPs, all bets are off.

By understanding the purpose of these hormones and how they are
manufactured, distributed and regulated, BE'ers can more effectively
apply the knowledge to their own unique situations.


2. Positive Feedback.
If the number of cells that need estrogen are great enough, then
estrogen production is increased to fill the need.


3. Negative Feedback:
Hormones that are produced are expected to fill targeted cells in
order for the cell to complete a DNA inscription and output a
protein or a fat, or some other form of potential energy. In our
case, we are interested in cells with estrogen receptor sites. When
estrogen receptor sites are filled to some level, the need is
filled. If there is some form of excess, negative feedback occurs
due to that excess estrogen in the blood which is not being used.
Estrogen production is lowered or stopped to maintain what is needed
but no more. It works somewhat like this:

https://img14.photobucket.com/albums/v43/Wahaika/EstrogenFeedbackLogic
.gif

Another way that estrogen is manufactured is through adipose fat
tissue. That is why BE 'ers use topicals - to fill the receptors
locally to stimulate the process that takes place locally.


4. Homeostasis:
When women start BE, their systems begin in a "balance." That is,
while their system as a whole may even be out of balance, the number
of receptors and the amount of hormones are at a standoff which
neither increases nor decreases breast tissue. The purpose of BE is
to tip this "balance" in favor of breast growth. It works somewhat
like this:

http://img.photobucket.com/albums/v43/Wahaika/ReceptorGrowthCycle.gif

It is important to note that these levels are all subjectively
placed. The purpose of the diagrams is to show the mechanics of the
process. The actual levels of hormone and resulting growth are
unknown and probably unique to each individual.

Someone starting at AAA Cup will have a slower go of it than someone
starting at B due to available receptor sites, and the less
forgiving closer thresholds. There is not enough wiggle room
sometimes, so you have to have it exactly right.

So, as a method, start with low dosages on a few herbs and then
evaluate if you have grown, or feel the growing aches, iches or
tingles. If you do, then maintain what you are doing. If not, add
something else or bump up the dosage of an existing herb.

A good starting point is 500mg per herb. Ramp up on those one at a
time also to get your body used to them.

Learn what each herb does do you can make a good decision on what to
bump up.

Don't forget the teas and massaging.

Basically (in order of my preference) :
Fenugreek - The most potent estrogenic herb
Fennel - The next most potent estrogenic herb
Saw Palmetto - An "anti androgen" (really a DHT blocker)
Wild Yam - Estrogenic Herb (up in the air)

Red Clover - Estrogenic and Progesterone blocker (I don't recommend
this one but others do so I'll list it.)

Oregano - Progesterone blocker
Damiana - Progesterone blocker

I have not yet seen a routine that uses all of these.

5. Blockers:
The use of "blockers" is simply using an herb that fills receptor
cells thus keeping the real hormone from filling those cells. This
results in negative feedback for that hormone if enough cells are
filled. The hormone is 'blocked."

Some examples of herbs used as blockers are Oregano as a
Progesterone blocker and Saw Palmetto as an androgen blocker.
Although, what probably happens with Saw Palmetto is that it keeps
testosterone from converting to Dihydrotestosterone (DHT) by filling
DHT receptors, thus keeping more testosterone available to aromatize
into estrogen. I am unaware of any studies that find Saw Palmetto
fills testosterone receptors or androstenedione receptors. On the
other hand, it may not have been studied either. Fenugreek and other
phytoestrogens are considered to be Estrogen blockers, if used to
that extent. BE'ers try and keep below those levels.

Perhaps the reason progesterone needs to be blocked is because it
competes with androgens for pregenalone. By blocking progesterone
there is more pregenalone available to go down the adrogen pathway
on its way to becoming estrogen, as long as the extra testosterone
is used.

6. Stalling
Basically, a stall happens when growth stops and does not start
again. Stalling could happen in several ways.

Direct: When all or nearly all receptors of a certain type are
continually filled, this seems to result in a stall. This appears to
be a function of negative feedback.

Indirect: When a hormone higher in the chain is blocked, the rest of
the chain essentially starves from lack of hormone. Production of
that hormone cannot continue due to lack of resources.

-Example: Estrogen is blocked by phytoestrogens to the extent that
negative feedback occurs and growing stops.

-Example: If testosterone is blocked, then estrogen will be blocked
because it is downstream from testosterone.

-Example: If there is not enough pregenalone to create progesterone
and enough estrogen (for BE), then progesterone could consume enough
pregenalone to starve the DHEA path, as far as BE'ers are concerned.

-Example: Too much testosterone is converted into DHT, therefore
keeping it from converting into estrogen.

Perhaps a strategically placed blocker can overcome many of these
stalls by allowing more of the parent hormone to follow the path to
it.

-Example: Progesterone blockers can allow more pregenelone to be
available to go down the DHEA path, thus making it available for
testosterone production for conversion into estrogen via aromatase.

-Example: Using a DHT blocker can allow more testosterone to be
available to be converted into estrogen.

Lowering below the negative feedback line may not be enough to
recover quickly from a stall. It is possible, that in order to
recover from a stall that the blood levels of estrogen/phytoestrogen
must be lowered below the positive feedback line.

For those in the AAAAAAA category, there are relatively fewer
receptors to begin with. Therefore stalling is easier to do. In fact
it might even be hard to avoid. For these women, it is not
necessarily true that the program "not working." The program may be
working just fine. They are simply stalling at lower levels because
of a low estrogen receptor count.

Perhaps in this case, starting over after a sufficient break, and
ramping up slowly with evaluation points (a week or two for every
500mg step, for example) should be added.


Cycling:

Keeping your body guessing. Missing dosages can be a form of
cycling. Adding progesterone on one cycle out of three is a form of
cycling because it is said to clear estrogen receptors.

Massaging every other day instead of every day is a form of cycling.

Dowsing is a form of cycling.

In a nutshell: Filling receptors and allowing them to empty in any
form of frequency. This probably guards against the negative
feedback system downregulating.


Question: How do BE'ers draw hormones in a given direction in the
steroid hormone cascade?

Answer: By using a BE routine to create tissue which the endocrine
system will create more cells with estrogen receptors and the body
should adjust homeostasis through negative feedback and maintain the
added tissue.

My thoughts on how much estrogen to use is different depending on
the number of estrogen receptors available - which may translate to
cup size.

https://img14.photobucket.com/albums/v43/Wahaika/ReceptorVolume.gif

As the area between the arrows goes down, the regimine uses lower
dosages and has to be more exact because there isn't enough room to
deviate.

So, here is how we are attacking this. (Much slower than last time)

Start with the infusions(herbal teas) at 1/2 strength then full
strength ASAP. Do the massages from day one.

Ramp up the internals to 500mg on each herb and give it a week or
two to allow time for the growth signs to appear. If there are none,
then go to 1000mg of each herb and do the same. Keep going in
approximately 500mg increments until growth signs appear.

Once growth signs appear, then record that level. If one is in the
AAA to AA range then stop there. If AA or greater then adjust up as
necessary. Maybe add a progesterone blocker NOT progesterone cream.

Otherwise, one could keep adjusting up to find the negative feedback
limit (the stall wall ) and then know what their growth range is.
They can then lower the dosage to the upper half of the range.

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